@article {329,
	title = {Genetic background influences the effect of thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice.},
	journal = {Sci Rep},
	volume = {11},
	year = {2021},
	month = {2021 06 24},
	pages = {13285},
	abstract = {<p>Growing evidence indicates that thirdhand smoke (THS) exposure induces many adverse health effects. However, it is unclear how THS exposure affects behavior and how host genetic background modulates phenotypic changes. Here we used the Collaborative Cross (CC) mouse population-based model to assess behavioral alterations immediately after THS exposure from 4 to 9\&nbsp;weeks of age. We first measured anxiety-like behavior in six strains using light/dark box combined with a custom multivariate mouse tracking system. We developed an anxiety risk scoring system based on anxiety-related traits and then evaluated the THS impact on them. THS exposure significantly decreased anxiety risk in CC019 (P = 0.002) and CC051 (P = 0.009), but increased anxiety risk in CC036 (P \&lt; 0.001), while the other three strains did not show significant changes in anxiety-related traits. Such differences were driven by female mice for the six measures of anxiety-like behavior. Memory potential was measured in the same cohort of mice using the passive avoidance assay. Both THS-exposed male and female CC019 mice displayed significant memory loss compared to controls while no significant changes were found in the other five strains. This study provides strong evidence that THS exposure leads to strain-dependent changes in anxiety-like behavior and memory, suggesting that host genetic variations play a critical role in individual susceptibility to THS-induced effects.</p>
},
	keywords = {Animals, Anxiety, Collaborative Cross Mice, Female, Humans, Male, Memory, Risk Factors, Tobacco Smoke Pollution},
	issn = {2045-2322},
	doi = {10.1038/s41598-021-92702-1},
	author = {He, Li and Wang, Pin and Schick, Suzyann F and Huang, Abel and Jacob, Peyton and Yang, Xu and Xia, Yankai and Snijders, Antoine M and Mao, Jian-Hua and Chang, Hang and Hang, Bo}
}
@article {322,
	title = {Identification of a novel 15-gene expression signature predicting overall survival of human colorectal cancer.},
	journal = {Clin Transl Med},
	volume = {10},
	year = {2020},
	month = {2020 Dec},
	pages = {e258},
	issn = {2001-1326},
	doi = {10.1002/ctm2.258},
	author = {Jiang, Chengfei and Zhao, Yue and Yuan, Binbin and Chang, Hang and Hang, Bo and Snijders, Antoine M and Mao, Jian-Hua and Zou, Xiaoping and Wang, Pin}
}
@article {308,
	title = {Thirdhand smoke: Genotoxicity and carcinogenic potential.},
	journal = {Chronic Dis Transl Med},
	volume = {6},
	year = {2020},
	month = {2020 Mar},
	pages = {27-34},
	abstract = {<p>Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS, has been well documented as a risk factor for human cancers, especially lung cancer. However, the concept of THS as a distinct entity that poses health risks for small children has developed only recently and the associations of THS with cancer risk and other chronic diseases are poorly understood due to limited numbers of studies to date. In this perspective, we mainly summarize all published studies on the genotoxicity and carcinogenic potential of THS exposure. These studies begin to fill the knowledge gap in our understanding of cancer risk of THS. Accumulating data from existing and future studies will help reduce the tobacco-related cancer incidence through changes in lifestyle and tobacco control policies.</p>
},
	issn = {2589-0514},
	doi = {10.1016/j.cdtm.2019.08.002},
	author = {Hang, Bo and Wang, Pin and Zhao, Yue and Hang Chang and Mao, Jian-Hua and Snijders, Antoine M}
}
