@article {326,
	title = {A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.},
	journal = {Sci Rep},
	volume = {12},
	year = {2022},
	month = {2022 01 27},
	pages = {1484},
	abstract = {<p>Radiotherapy is the current standard of care for more than 50\% of all cancer patients. Improvements in radiotherapy (RT) technology have increased tumor targeting and normal tissue sparing. Radiations at ultra-high dose rates required for FLASH-RT effects have sparked interest in potentially providing additional differential therapeutic benefits. We present a new experimental platform that is the first one to deliver petawatt laser-driven proton pulses of 2\&nbsp;MeV energy at 0.2\&nbsp;Hz repetition rate by means of a compact, tunable active plasma lens beamline to biological samples. Cell monolayers grown over a 10\&nbsp;mm diameter field were exposed to clinically relevant proton doses ranging from 7 to 35\&nbsp;Gy at ultra-high instantaneous dose rates of 10\&nbsp;Gy/s. Dose-dependent cell survival measurements of human normal and tumor cells exposed to LD protons showed significantly higher cell survival of normal-cells compared to tumor-cells for total doses of 7\&nbsp;Gy and higher, which was not observed to the same extent for X-ray reference irradiations at clinical dose rates. These findings provide preliminary evidence that compact LD proton sources enable a new and promising platform for investigating the physical, chemical and biological mechanisms underlying the FLASH effect.</p>
},
	keywords = {Cell Line, Humans, Lasers, Monte Carlo Method, Neoplasms, Proton Therapy, Radiation Oncology, Radiobiology, Radiometry, Radiotherapy Dosage, Synchrotrons},
	issn = {2045-2322},
	doi = {10.1038/s41598-022-05181-3},
	author = {Bin, Jianhui and Obst-Huebl, Lieselotte and Mao, Jian-Hua and Nakamura, Kei and Geulig, Laura D and Chang, Hang and Ji, Qing and He, Li and De Chant, Jared and Kober, Zachary and Gonsalves, Anthony J and Bulanov, Stepan and Celniker, Susan E and Schroeder, Carl B and Geddes, Cameron G R and Esarey, Eric and Simmons, Blake A and Schenkel, Thomas and Blakely, Eleanor A and Steinke, Sven and Snijders, Antoine M}
}
