Background

Prognosis of breast cancer (BC) patients differs considerably. Therefore, identify a reliable prognostic biomarker to distinguish patients with poor prognosis. Increasing evidence shows that the microbiome plays a critical role in cancer development and progression, and therapies. Moreover, with the development of microbiome technologies, researchers have revealed the variation in the abundance and composition of intratumor microbiome.

Specific Aims and Significance

In this project, we sought to identify a microbiome signature for predicting the prognosis of patients with breast cancer. This study will provide a new avenue for developing biomarkers for personalized medicine by incorporating cancer microbiome.

Research Team

This project is led by April W Mao, Jacob Young, Henrik Barck, and Anthony Paley​  from Campolindo High School.

Publication

A. W. Mao, H. Barck, J. Young, A. Paley, J. ‑H. Mao and H. Chang, Identification of a novel cancer microbiome signature for predicting prognosis of human breast cancer patients, Clinical and Translational Oncology, 2021 (https://doi.org/10.1007/s12094-021-02725-3)