A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.

TitleA new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.
Publication TypeJournal Article
Year of Publication2022
AuthorsBin J, Obst-Huebl L, Mao J-H, Nakamura K, Geulig LD, Chang H, Ji Q, He L, De Chant J, Kober Z, Gonsalves AJ, Bulanov S, Celniker SE, Schroeder CB, Geddes CGR, Esarey E, Simmons BA, Schenkel T, Blakely EA, Steinke S, Snijders AM
JournalSci Rep
Volume12
Issue1
Pagination1484
Date Published2022 01 27
ISSN2045-2322
KeywordsCell Line, Humans, Lasers, Monte Carlo Method, Neoplasms, Proton Therapy, Radiation Oncology, Radiobiology, Radiometry, Radiotherapy Dosage, Synchrotrons
Abstract

Radiotherapy is the current standard of care for more than 50% of all cancer patients. Improvements in radiotherapy (RT) technology have increased tumor targeting and normal tissue sparing. Radiations at ultra-high dose rates required for FLASH-RT effects have sparked interest in potentially providing additional differential therapeutic benefits. We present a new experimental platform that is the first one to deliver petawatt laser-driven proton pulses of 2 MeV energy at 0.2 Hz repetition rate by means of a compact, tunable active plasma lens beamline to biological samples. Cell monolayers grown over a 10 mm diameter field were exposed to clinically relevant proton doses ranging from 7 to 35 Gy at ultra-high instantaneous dose rates of 10 Gy/s. Dose-dependent cell survival measurements of human normal and tumor cells exposed to LD protons showed significantly higher cell survival of normal-cells compared to tumor-cells for total doses of 7 Gy and higher, which was not observed to the same extent for X-ray reference irradiations at clinical dose rates. These findings provide preliminary evidence that compact LD proton sources enable a new and promising platform for investigating the physical, chemical and biological mechanisms underlying the FLASH effect.

DOI10.1038/s41598-022-05181-3
Alternate JournalSci Rep
PubMed ID35087083
PubMed Central IDPMC8795353
Grant ListDE-AC02-05CH11231 / / Laboratory Directed Research and Development /
DE-AC02-05CH11231 / / U.S. Department of Energy /